Molecular Exploitation of Apoptosis Pathways in Prostate Cancer
Wydanie: 2012 r.
Dostępność: aktualnie niedostępny
This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.Contents:Introduction: Prostate CancerThe Prostate Gland DynamicsApoptosis Pathways Signaling Execution of Cancer CellsAndrogen Receptor-Mediated Apoptosis: Significance in Development of Castration-Resistant Prostate CancerAnoikis in Prostate Cancer MetastasisEpithelial–Mesenchymal Transition (EMT) in Prostate Cancer MetastasisNovel Molecular Therapeutics for Targeting Castration-Resistant Prostate CancerApoptotic-Based Molecular Markers of Therapeutic ResponseRole of Apoptosis in Prostate Cancer PreventionSummary and Future DirectionsReadership: Practising clinicians including urologists, pathologists, medical oncologists and scientists with an interest in cancer, especially prostate cancer.